《生命科学》 2011, 23(3): 286-290

IL-23/Th17轴在变应性哮喘中的研究进展

杨　影¹，罗　英^1*，李春林¹，杨春平¹，罗　璝¹，付明福²，廖新根²

(1 南昌大学第二附属医院耳鼻咽喉-头颈外科，南昌 330006；2 南昌大学第二附属医院骨科，南昌 330006)

摘　要：摘　要：变应性哮喘是一种由辅助性T细胞 (T helper cell， Th cell)调节的慢性炎症性疾病。Th1/Th2的失衡一直被认为是变应性哮喘的发病机制，Th2细胞及其分泌的细胞因子白介素4(interleukin 4， IL-4)、IL-5以及IL-13在变应性哮喘特异性症状的发病中发挥重要作用。最近研究发现Th17细胞及其分泌的IL-17参与变应性哮喘的发展过程，IL-23在Th17细胞维持生存和功能成熟中发挥重要作用，并参与抗原诱导的气道炎症反应。该文对目前IL-23/Th17轴在变应性气道炎症反应中的研究进展作一综述。
关键词：IL-23；Th17；IL-17；哮喘

Recent progress of IL-23/Th17 axis in allergic asthma

YANG Ying¹， LUO Ying^1*， LI Chun-Lin¹， YANG Chun-Ping¹， LUO Gui¹， FU Ming-Fu²， LIAO Xin-Gen²

(1 Otolaryngology - Head and Neck Surgery， The Second Affiliated Hospital of Nanchang University， Nanchang 330006， China; 2 Orthopedics， The Second Affiliated Hospital of Nanchang University， Nanchang 330006， China)

Abstract:
Abstract: Allergic asthma is a chronic inflammatory disease regulated by the T helper (Th) cells. The Th1/Th2 imbalance has been well documented in the pathogenesis of allergic asthma， Th2 cells and their cytokines such as interleukin 4 (IL-4)， IL-5， and IL-13 orchestrate these pathognomonic features of asthma. Recently， Th17 cells and IL-17 have been found to participate in the development of allergic asthma， IL-23， which is essential for survival and functional maturation of Th17 cells， is involved in antigen-induced airway inflammation. In this review， current understanding of the roles of IL-23/Th17 axis in allergic airway inflammation will be summarized.
Key words: IL-23; Th17; IL-17; asthma