《生命科学》 2011, 23(3): 283-285

钙网蛋白与神经系统病变

罗　飞，柳长柏^*

(三峡大学分子生物学研究所，宜昌 443002)

摘　要：
摘　要：钙网蛋白(calreticulin，CRT)是内质网中的一种多功能的分子伴侣，在协助蛋白质正确折叠和维持细胞Ca2+稳态(Ca2+信号)中发挥重要作用。近来的研究发现，钙网蛋白与神经系统病变包括阿尔茨海默氏病、帕金森病等有密切关系。
关键词：钙网蛋白；神经系统病变；阿尔茨海默氏病；帕金森病

Calreticulin and nervous system diseases

LUO Fei， LIU Chang-Bai^*

( Institute of Molecular Biology， China Three Gorges University， Yi Chang 443002， China)

Abstract:
Abstract: Calreticulin(CRT) is a kind of multi-functional protein in endoplasmic reticulum(ER)， which plays important roles in a variety of cellular processes including Ca2+ signaling/ homeostasis and protein folding. Recent studies show that CRT is closely relevant with nervous system diseases， including Alzheimer{$39}s disease， Parkinson{$39}s disease.
Key words: calreticulin; nervous system diseases;  Alzheimer{$39}s disease;  Parkinson{$39}s disease