《生命科学》 2011, 23(3): 267-272

移植物抗宿主病和移植物抗白血病相关细胞因子的研究进展

曹琳琳，孙自敏^*

(安徽医科大学附属省立医院血液科，合肥 230000)

摘　要：摘　要：异基因造血干细胞移植(allogeneic hemotoic stem cell transplantation， allo-HSCT)是治疗血液系统恶性肿瘤的有效方法，治疗效果主要依赖于移植物抗白血病效应(graft-versus-leukemia， GVL)，可以清除残存肿瘤细胞， 达到完全治愈恶性血液病的目的。然而，GVL与allo-HSCT的并发症移植物抗宿主病(graft-versus-host disease， GVHD)紧密相连。通过合理调节一些细胞因子的作用可以达到降低GVHD、保留GVL的目的。该文就GVHD与GVL发生机制中相关细胞因子作用的研究进展做一综述。
关键词：移植物抗宿主病； 移植物抗白血病效应； 细胞因子

Progress on research of cytokines in graft-versus-host disease and graft-versus-leukemia

CAO Lin-Lin， SUN Zi-Min^*

(Department of Hematology， Provincial Hospital， Anhui Medical University， Hefei 230000， China)

Abstract: Abstract: Allogeneic hemotoic stem cell transplantation (allo-HSCT) is now an effective treatment for multiple malignant hematological tumors. Graft-versus-leukemia (GVL) after allo-HSCT can eliminate residual tumor cells and improve survivals， while it is closely related with severe graft-versus-host diseases(GVHD). Now many scientists reached an agreement that by controlling the role of some cytokines can achieve the purpose of reducing GVHD as well as remain GVL. This review provides a discussion of the current state of the literature regarding the key GVHD and GVL cytokines and their capacity to predict clinical disease outcome.
Key words: graft-versus-host disease; graft-versus-leukemia; cytokines