《生命科学》 2011, 23(3): 261-266

人乳头状瘤病毒感染与肺癌关系的研究进展

李　刚， 何　丽， 唐旭东^*

(广东医学院生物化学与分子生物学教研室，湛江 524023)

摘　要：摘　要：近年越来越多的研究发现肺癌组织中有人乳头状瘤病毒(human papillomavirus，HPV)DNA和癌蛋白的检出，其检出率具有地域差异性，但不同地方HPV检出亚型具有高度的一致性，主要是高危型HPV-16和HPV-18。HPV可能主要通过血液循环从宫颈癌病灶等原发部位转移到肺，从而可能诱发肺癌的发生。HPV诱发肺癌的机制可能与影响p53 的失活及端粒酶的激活等有关。
关键词：人乳头状瘤病毒；肺癌；p53；端粒酶

Research progress of relationship between human papillomavirus infection

LI Gang， HE Li， TANG Xu-dong^*

(Department of Biochemistry and Molecular Biology， Guangdong Medical College， Zhanjiang 524023， China)

Abstract: Abstract: In recent years， a number of studies showed that HPV-DNA and oncoproteins were detected in lung cancer tissues. The detection rate was from 0 to 80% with the differences of regions， but there was no significant difference between HPV subtypes in lung cancer， and high-risk types HPV -16 and -18 were most frequently at present. HPV infected lung from primary cervical cancer may mainly through blood circulation. The mechanism of HPV-induced lung cancer may be related to inactivation of p53 and activation of telomerase.
Key words: human papillomavirus; lung cancer; p53; telomerase