《生命科学》 2011, 23(1): 70-76

丙型肝炎病毒准种及其临床意义研究进展

何立华¹，李　峥²，夏雪山^1*

(1昆明理工大学生命科学与技术学院，分子病毒学实验室，昆明 650224；2昆明医学院附属昆华医院，昆明650032

摘　要：
摘 要：丙型肝炎病毒(HCV)易发生变异，在宿主体内主要以准种形式存在。HCV准种能够参与病毒逃避宿主的免疫监控及抗病毒治疗的耐药性，导致病毒在宿主体内持续存在，形成慢性感染。该文就HCV准种的产生、研究方法、基因组各区段内准种的研究及其临床意义作一综述。
关键词：HCV；准种；变异

Research progress on hepatitis C virus quasispecies and its clinical significance

HE Li-Hua¹， LI Zheng²， XIA Xue-Shan^1*

1 Laboratory of Molecular Biology， Faculty of Life Science and Technology ， Kunming University of Science and Technology， Kunming 650224， China; 2 Department of Clinical Laboratory， the First People‘s Hospital of Yunnan Province， Kunming 650032， China

Abstract: Abstract:  Hepatitis C virus (HCV)， with highly genetic variation， was characterized by the existence of a wide quasispecies distribution within a single infected individual. It was proved HCV quasispecies play an important role in the virus escaping from the host immunosurveillance and the resistance to antiviral therapy， which lead to the chronic virus infection and persistent pathogenicity. Here， we summarized the generation of HCV quasispecies， the research of quasispecies?characters within each gene of HCV genome， and its clinical significance.
Key words:  HCV; quasispecies; variability