《生命科学》 2011, 23(1): 26-31

泛素/26S蛋白酶体系统介导的细胞程序化死亡

王国坤，田风霞，宫江峰，王　玮^*

山东农业大学生命科学学院，作物生物学国家重点实验室，泰安271018

摘　要：摘　要：在一定的生理或者病理条件下，细胞为了自身发育或者抵御不良刺激，会采取细胞程序化死亡(programmed cell death， PCD)的方式结束生命。泛素/26S蛋白酶体系统(ubiquitin-26S proteasome system， UPS)作为生物体中重要的翻译后蛋白质调节系统，对PCD起着关键的调节作用。该文介绍UPS通过两条细胞凋亡信号转导通路以及天冬氨酸特异性半胱氨酸蛋白酶来调控PCD的研究进展。
关键词：细胞程序化死亡；泛素/26S蛋白酶体系统；天冬氨酸特异性半胱氨酸蛋白酶；凋亡抑制因子

Programmed cell death mediated by ubiquitin-26S proteasome system

WANG Guo-Kun， TIAN Feng-Xia， GONG Jiang-Feng， WANG Wei^*

State Key Laboratory of Crop Science， College of Life Sciences， Shandong Agricultural University， Taian 271018， China

Abstract: Abstract：Programmed cell death (PCD) is an active process， by which cells choose to die for development or in response to environment. Ubiquitin-26S proteasome system (UPS) as a post-translational regulatory system， plays a prominent role in regulation of initiation and progress of PCD. Here we summarize the major findings on the function of UPS in PCD regulation by two signal approachs and caspases.
Key words：programmed cell death；ubiquitin-26S proteasome system；caspase；inhibitor of apoptosis