《生命科学》 2011, 23(1): 13-18

ABCC4与人类肿瘤

石　妮，赵晓航^*

中国医学科学院/北京协和医学院肿瘤研究所，分子肿瘤学国家重点实验室，北京100021

摘　要：摘　要：ABCC4(ATP-binding cassette transporter family class C4， ABCC4)是ABC蛋白家族成员，主要参与转运机体物质代谢中产生的有机阴离子和一些异型生物质等生物学功能。近年研究发现某些人类肿瘤存在Abcc4基因的拷贝数变异，主要表现为Abcc4基因拷贝数增加和ABCC4蛋白过表达，这些改变与肿瘤发生发展、耐药，以及治疗疗效具有相关性。该文综述了Abcc4基因的拷贝数变异和异常表达与肿瘤生物学特性的关系，探讨ABCC4在肿瘤发生发展中的作用机制。
关键词：ABC转运蛋白家族4；拷贝数变异；肿瘤抗药性

ATP-binding cassette transporter family class C4 and human cancer

SHI Ni， ZHAO Xiao-Hang^*

State Key Laboratory of Molecular Oncology， Cancer Institute of Chinese Academy of Medical Sciences & Peking Union Medical College， Beijing 100021， China

Abstract: Abstract: ATP-binding cassette transporter family class C4 (ABCC4) is known as a member of the ATP-binding cassette transporter super-family， involved in the active transport of endogenous anions and xenobiotic， which is not normally produced or expected to be present in human， such as antibiotics. Recently it has been found that the copy number variations of Abcc4 gene and overexpression of ABCC4 protein in many kinds of human cancers， which might involved in tumorigenesis， progress and chemotherapeutic response. This review will focus on the ectopic expression of Abcc4 in human cancer and the potential role of ABCC4 in tumorigenesis and progress.
Key words: ATP-binding cassette transporter family class C4; copy number variation; chemotherapeutic resistance