《生命科学》 2010, 22(12): 1259-1263

瞬时受体电位香草酸亚型1(TRPV1)与炎性痛

贾　岳 ，洪炎国*

(福建省发育与神经生物学重点实验室，福建师范大学生命科学学院，福州350108)

摘　要：

 

    

摘　要：瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1，TRPV1)是TRP超家族的成员之一，是一种非选择性的阳离子通道。TRPV1广泛分布于伤害性感受器上，并且在伤害性感受器中起重要作用。TRPV1能够感受伤害性刺激，将之转化为动作电位，传至中枢形成痛觉。炎症时释放的许多炎症介质都能够与TRPV1发生相互作用，产生疼痛或痛觉过敏，并且通过各种不同的信号通路来调制TRPV1的活性。深入研究TRPV1的作用机制，有助于理解痛觉生理和开发新型镇痛药物。
关键词：TRPV1；炎症介质；痛觉过敏
中图分类号：R971.1; Q432; R364.5  文献标识码：A

    

 

Transient receptor potential vanilloid 1 (TRPV1) and inflammatory pain

JIA Yue， HONG Yan-guo*

(Key Laboratory of Developmental Neurobiology and Neuroscience in Fujian Province，College of Life Science， Fujian Normal University， Fuzhou 350108， China)

Abstract: Abstract：Transient receptor potential vanilloid 1(TRPV1) is one of members of TRP superfamily. TRPV1 is a non-selective cation channel. It is located in nociceptors and plays an important role in nociceptive processing. TRPV1 can detect noxious stimulus and convert it into action potentials traveling to the central and forming pain sensation. In inflammatory pain， a number of inflammatory mediators are released， which modulate TRPV1 activity through various signal pathways or interact with TRPV1 generating pain or hyperalgesia. Study on role of TRPV1 and its mechanisms will help us to understand pain physiology and to develop new analgesic drugs.
Key words：TRPV1; inflammatory mediators; hyperalgesia