摘 要：摘 要：芳香烃受体核转位蛋白(aryl hydrocarbon receptor nuclear translocator，ARNT)是碱性螺旋-环-螺旋转录因子超家族中新发现的PAS亚家族的成员之一。它是体内许多bHLH-PAS蛋白共同的专性配偶体，可以与芳香烃受体、低氧诱导因子、果蝇SIM蛋白等形成异二聚体并介导许多信号转导过程，从而使个体对环境污染物(如二恶英)、低氧状态等外界因素的改变产生相应的生物学效应，本文就ARNT的基本结构及其在体内的主要生理功能等方面作一综述。
关键词：芳香烃受体核转位蛋白；转录因子；芳香烃受体
Abstract: Abstract: The aryl hydrocarbon receptor nuclear translocator (ARNT) belongs to the basic helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) family of transcription factors, which, in addition to the bHLH motif, contains a PAS region of homology. It contains a basic DNA binding sequence adjacent to a helix-loop-helix dimerization domain. ARNT binds to DNA in the form of a heterodimer with the aryl hydrocarbon receptor (AhR), hypoxia-inducible factor 1a (HIF-1a), SIM proteins, and mediates a variety of signal transduction such as environmental pollutants (dioxin) and hypoxia , respectively. ARNT controls critical developmental and metabolic processes.
Key words: aryl hydrocarbon receptor nuclear translocator (ARNT); transcription factors; aryl hydrocarbon receptor (AhR)
