《生命科学》 2010, 22(12): 1241-1246

细胞因子与酒精性肝病

刘丽琼1，2，骆　嘉1，柯尊记1*

(1 中国科学院上海生命科学研究院营养科学研究所，营养与代谢重点实验室，上海200031；

摘　要：

摘　要：酒精性肝病(alcoholic liver disease， ALD)的发生发展过程与体内多种细胞因子有关，尤其是肿瘤坏死因子-a(tumor necrosis factor-a， TNF-a)和转化生长因子-b(transforming growth factor-b， TGF-b)在调节肝细胞的凋亡过程中具有重要作用。TNF-a可引起肝细胞凋亡与炎症反应等，抗TNF-a治疗能明显减轻酒精引起的肝损害; TGF-b具有增加细胞外基质的合成和抑制细胞外基质降解的作用，TGF-b1升高与肝纤维化密切相关。细胞因子可能是防治酒精性肝病的有效分子靶点。
关键词：酒精性肝病；肿瘤坏死因子-a；转化生长因子；炎症反应
中图分类号：R573; R392.32  文献标识码：A

    

 

The role of cytokines in the progress of alcoholic liver disease

LIU Li-qiong 1，2， LUO Jia1， KE Zun-Ji 1*

(1 Key Laboratory of Nutrition and Metabolism， Institute for Nutritional Sciences， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China; 2 Shanghai University of Traditional Chinese Medicine， Shanghai 20120

Abstract:

Abstract: Cytokines， especially tumor necrosis factor-a (TNF-a) and transforming growth factor-b(TGF-b)， play an important role in the mechanisms in the pathogenesis of alcoholic liver disease (ALD)， such as steatohepatitis， fibrosis， and cirrhosis. TNF- a and TGF-b are involved in the apoptotic liver cell death. TNF-a also takes part in the inflammation related to ALD. TNF-a antibody can distinctly alleviate alcohol-induced liver injury. TGF-b can increase extracellular matrix synthesis and inhibit its degradation; TGF-b1 is intimately related to the alcoholic liver fibrosis. Cytokines are promising targets for preventing and treatment of the ALD.
Key words: alcoholic liver disease; tumor necrosis factor-a; transforming growth factor; inflammation