《生命科学》 2010, 22(11): 1192-1195

多发性骨髓瘤与白细胞介素-6

王建军，洪丽萍，汤立军*

中南大学生物科学与技术学院分子生物学研究中心，长沙410078

摘　要：摘　要：白细胞介素-6是多发性骨髓瘤(multiple myeloma，MM)瘤细胞生长和生存的关键因子，也是MM患者发病的主要因子。IL-6/IL-6R系统通过不同通路影响多发性骨髓瘤瘤细胞生长并导致患者骨损害、类风湿性关节炎等一系列并发症。针对IL-6/IL-6R系统的治疗方法将给MM的治疗带来重大的进展。
关键词：IL-6/IL-6R；gp130；多发性骨髓瘤

Multiple myeloma and interleukin-6

WANG Jian-jun， HONG Li-ping， TANG Li-jun*

Molecular Biology Research Center， Institute of Life Science and Technology， Central South University， Changsha 410078， China

Abstract: Abstract: Interleukin-6 is a key growth and survival factor， which is involved in tumorigenesis of multiple myeloma. The proliferation of malignant cells in multiple myeloma are affected through different pathways of IL-6/IL-6R ，which also could lead to bone damage， rheumatoid arthritis and some other complications in patients. Treatment of MM targeted IL-6/IL-6R system will provide a new therapeutic approach based on interruption of IL-6 mediated tumor cell growth in future.
Key words: IL-6/IL-6R; gp130; multiple myeloma