《生命科学》 2010, 22(11): 1147-1153

上皮细胞向间质细胞转变的调控及其与细胞凋亡的关系

宋建国*，王冬梅

中国科学院上海生命科学研究院生物化学与细胞生物学研究所， 上海 200031

摘　要：
摘　要：上皮细胞向间质细胞的转变(EMT)是一种十分广泛而重要的生物学过程，对于胚胎发育、细胞分化和迁移以及生物体内稳态的维系起着极其重要的作用。EMT与癌细胞的转移以及组织的纤维化也密切相关。此外，细胞的凋亡/存活和分化命运的选择也受到EMT的深刻影响。因此，EMT参与诸多生理病理现象的发生发展过程，了解其调控机制有助于认识这些过程和相关疾病的发生条件与基础。该文就转化生长因子-b(TGF-b)介导的EMT及其与细胞凋亡命运的关系作一简单综述。
关键词：上皮细胞向间质细胞的转变；细胞凋亡；细胞周期；转化生长因子-b

Epithelial-to-mesenchymal transition and its relation with apoptosis

SONG Jian-guo*， WANG Dong-mei

Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China

Abstract: Abstract: Epithelial-to-mesenchymal transition (EMT) is a critical and widely occuring biological process，which plays critical roles in embryonic development， cell differentiation， migration， and body homeostasis. EMT is also closely related with cancer metastasis and tissue fibrosis. In addition， the determination of cellular fates of apoptosis/survival and differentiation is deeply influenced by EMT. Thus， EMT has been implicated in various physiological and pathological events. Exploring the regulatory mechanism of EMT can be of very helpful in understanding the basic aspects of patho-physiological events and the development of relevant diseases. Here， we briefly reviewed the TGF-b-mediated EMT and its relationship with cell apoptosis fate.
Key words: epithelial-to-mesenchymal transition; apoptosis; cell cycle; TGF-b