《生命科学》 2010, 22(11): 1129-1137

对称蛋白质序列与结构关系研究

肖 奕*，冯建辉，黄延昭

华中科技大学物理学院生物分子物理与模拟研究组，武汉 430074

摘　要：摘　要：进化的观点认为，蛋白质结构的对称性是基因复制和融合的结果，但是由于在长期进化过程中的氨基酸突变，绝大多数现有的蛋白质序列都失去了这种直观的重复性特征。该文简要地回顾了国际上发展的寻找蛋白质序列中重复片段的方法，重点介绍了作者自己提出的分析蛋白质序列和结构对称性的方法以及在蛋白质对称结构形成机理方面的初步工作，并系统分析了各类对称折叠子的序列与结构关系，发现它们的序列都具有隐含的与结构相同的对称性，或者说序列的对称性决定结构的对称性。
关键词：结构对称性；序列对称性；相似矩阵；基因复制；进化

Studies of sequence-structure relations of symmetric proteins

XIAO Yi*， FENG Jian-hui， HUANG Yan-zhao

Biomolecular Physics and Modeling Group， Department of Physics， Huazhong University of Science and Technology， Wuhan 430074， China

Abstract: Abstract: From the view of evolution， the symmetry of protein structure is the result of gene duplication and fusion. However， due to the mutation in evolution， most of proteins have lost their repetitive signals in sequences. In this paper we will briefly review the methods of detecting repeats in protein sequences. In particular， we shall introduce our methods of detecting sequence and structure symmetries of proteins as well as our studies in the mechanism of the formation of symmetric structures of proteins. We investigated the sequence-structure of different types of folds and found their hidden sequence symmetries as the structures or sequence symmetry encodes structural symmetry.
Key words: protein; structural symmetry; sequence symmetry; similarity matrix; gene duplication; evolution