摘 要：摘 要：在神经发育过程中，神经营养因子通过其低亲和力受体p75NTR与高亲和力受体Trk的介导，在神经元的存活、分化与髓鞘形成中发挥着重要的作用；与存活、生长这些“正性”信号相反，p75NTR也介导受损后及新生神经元凋亡这一“负性”信号。一直以来，p75NTR是如何介导这些截然相反的功能仍不清楚，尤其是何时引起凋亡，其机制如何更是所知甚少。近来，随着s-p75NTR、proNGF、sortilin复合受体等的发现，其中的一些机制开始有所明朗。本文就p75NTR介导神经元凋亡的研究进展做一综述。
关键词：p75NTR；凋亡；神经元
Abstract: Abstract: Neurotrophins are essential factors during neuronal development. They promote survival, differentiation and myelination of neurons via Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Paradoxically, compare to these "positive"roles, the p75 neurotrophin receptor also ensures some "negative" roles such as apoptosis of neonatal and injured neurons. Until recently, the mechanisms by which the p75 neurotrophin receptor governs these opposing functions have remained elusive. By the identification of new ligands and cytosolic interacting partners, receptor cleavage products and coreceptors such as: s-p75NTR, proNGF and sortilin, some of these mechanisms are now being unraveled. Here, we review recent progress in delineating the molecular networks that enable p75NTR to dictate neuroal apoptosis.
Key words: p75NTR; apoptosis; neurons
