《生命科学》 2010, 22(10): 1069-1073

SDF-1/CXCR4轴在骨再生修复中的研究进展

廖新根1，殷　明2，李士勇3*，吴梨华1，刘　哲1，付明福1

(1南昌大学研究生院医学部，南昌330006；2南昌大学第二附属医院骨科，南昌330006；3 南昌大学第二附属医院分子医学中心，南昌330006)

摘　要：

摘　要：基质细胞衍生因子-1(stromal cell-derived factor-1， SDF-1)及其受体CXCR4构成SDF-1/CXCR4轴系统具有许多重要的生物学特性和功能。近年来随着该领域的研究不断深入，越来越多的发现表明，SDF-1/CXCR4轴系统在组织损伤及修复中起着重要作用，其在骨组织再生修复中的作用也日益受到关注。该文主要对SDF-1/CXCR4轴系统的生物学特性及其在骨再生修复中的作用进行综述。
关键词：基质细胞衍生因子-1；SDF-1/CXCR4轴系统；生物学特性；骨再生修复
中图分类号：Q813；R683  文献标识码：A

    

 

Progress of SDF-1/CXCR4 axis in bone regeneration

LIAO Xin-gen1， YIN Ming2， LI Shi-yong3*， WU Li-hua1， LIU Zhe1， FU Ming-fu1

(1 Graduate School of Medicine， Nanchang University， Nanchang 330006， China; 2 Second Affiliated Hospital of Nanchang University， Nanchang 330006， China; 3 Center for Molecular Medicine， Second Affiliated Hospital of Nanchang University， Nanchang 330

Abstract:

Abstract: The SDF-1/CXCR4 axis system constituted by stromal cell-derived factor -1 (SDF-1) and its receptor CXCR4 has many important biological characteristics and functions. With deepening research in the field in recent years， the growing number of findings suggest that the SDF-1/CXCR4 axis system plays an important role in regeneration and repair of tissue injury ， what{$39}s more， the role of SDF-1/CXCR4 axis system in the regeneration of bone tissue are also increasingly concerned. This article reviews the biological characteristics of the SDF-1/CXCR4 axis system and its role in bone regeneration and repair.
Key words: stromal cell-derived factor-1; SDF-1/CXCR4 axis system; biological characteristics; bone regeneration and repair