《生命科学》 2010, 22(10): 1053-1068

发现靶向蛋白质间相互作用的小分子药物研究进展

聂爱华

(军事医学科学院毒物药物研究所，北京100850)

摘　要：

摘　要：蛋白质-蛋白质相互作用在多种细胞功能中具有重要的作用。靶向蛋白质-蛋白质相互作用已经成为新药发现的重要策略，但发现能阻断蛋白质-蛋白质相互作用的小分子药物是一个巨大的挑战。尽管如此，近年来人们还是发现了许多能调控蛋白质-蛋白质相互作用的小分子。该文主要总结了在病毒进入、细胞凋亡通路和神经退行性疾病等方面的蛋白质-蛋白质相互作用小分子抑制剂的研究进展。
关键词：蛋白质-蛋白质相互作用；小分子药物；抑制剂
中图分类号：Q51; R97-4 文献标识码：A

    

 

Recent progress in targeting protein-protein interactions for small-molecule drugs discovery

NIE Ai-hua

(Institute of Pharmacology and Toxicology， Academy of Military Medical Science， Beijing 100850， China)

Abstract: Abstract: Protein-protein interactions play a crucial role in numerous vital cell functions. Targeting protein-protein interactions is one of the most important strategies of drug discovery， but discovering small-molecule drugs that disrupt protein-protein interactions is an enormous challenge. However many small molecules which can modulate the protein-protein interactions have been discovered in the recent years. This review will focus on small-molecule inhibitors of protein-protein interactions in virus entry， apoptosis pathway and neurodegenerative diseases.
Key words: protein-protein interactions; small molecule drug; inhibitors