《生命科学》 2010, 22(10): 1047-1052

微重力条件下细胞培养和组织工程研究进展

雷晓华，宁立娜，曹宇静，段恩奎*

(中国科学院动物研究所生殖生物学国家重点实验室， 北京 100101)

摘　要：

摘　要：随着空间生命科学研究的发展，人们将细胞、组织培养技术与微重力环境相结合产生了组织工程研究的一个新领域——微重力组织工程。模拟微重力条件下细胞培养和组织构建研究表明，微重力环境有利于细胞的三维生长，形成具有功能的组织样结构，培养后的三维组织无论从形态上还是基因表达上都更接近于正常的机体组织。这种微重力对细胞的作用效应，将可能为未来组织工程和再生医学研究提供一条新途径。该文概述了近十年来国内外微重力组织工程相关研究的最新进展。
关键词：微重力；生物反应器；细胞培养；组织工程
中图分类号：R329.28; R329.3    文献标识码：A

    

 

Advances in cell culture and tissue engineering under microgravity

LEI Xiao-hua， NING Li-na， CAO Yu-jing， DUAN En-kui*

(State Key Laboratory of Reproductive Biology， Institute of Zoology， Chinese Academy of Sciences， Beijing 100101， China)

Abstract: Abstract: Along with the development of space biology， the technique of tissue and cell culture under microgravity is becoming a new research filed， which has been known as microgravity tissue engineering. The study of microgravity or simulated microgravity on cells and tissues culture indicated that microgravity could offer special effects on forming three-dimension (3-D) tissue structure and functional tissues. The 3-D tissue constructs generated on microgravity condition exhibit more similar phenotypes in either morphous or gene expression profiles to those in normal tissues. This review summarizes the recent advances of microgravity tissue engineering in the past 10 years.
Key words: microgravity ; bioreactor; cell culture; tissue engineering