《生命科学》 2010, 22(10): 1025-1030

气体分子硫化氢在炎症与免疫调节中的研究进展

郑一诫，储以微*

(复旦大学上海医学院免疫学系，上海200032)

摘　要：

摘　要：硫化氢(H2S)是具有生物学效应的气体小分子，它在免疫系统中亦发挥着重要的调节功能。H2S可通过影响IL-2(Interleukin-2)的合成抑制淋巴细胞增殖；可通过激活ERK激酶(extracellular regulated protein kinases)或者KATP通道(ATP-sensitive potassium channel)，促进单核巨噬细胞及中性粒细胞分泌促炎因子，导致组织损伤，诱导诸如溃疡性结肠炎、胃炎、急性胰腺炎、急性肺损伤及毒血症等多种炎症性疾病。相反，H2S还可诱导多种抑炎因子，发挥抑制炎症的作用。鉴于H2S在免疫与炎症中发挥的生理和病理效应，该文对H2S在炎症与免疫调节中的研究进展进行综述。
关键词：硫化氢；免疫调节；淋巴细胞；中性粒细胞；巨噬细胞
中图分类号：R392；R967；R331.1    文献标识码：A

    

 

Involvement of hydrogen sulfide in inflammation and immune regulation

ZHENG Yi-jie， CHU Yi-wei*

(Department of Immunology， Shanghai Medical College， Fudan University， Shanghai 200032， China)

Abstract:

Abstract: Hydrogen sulfide (H2S) is endogenously produced gaseous autacoids that participate in several physiologic processes. In recent years， evidence has accumulated to suggest important roles for H2S as a regulator in immune system. Exogenous H2S inhibits cell proliferation of lymphocytes subsets by reducing IL-2 secretion. H2S donors may enhance inflammatory response in neutrophil and macrophage via activation of ERK or KATP， which results in several inflammatory diseases such as colitis， gastritis， acute pancreatitis， acute lung injury， asthma and septicemia. On the other hand， H2S may induce some anti- inflammatory cytokines that suppress inflammatory response in some animal models. Here we overview the advanced researches in H2S and its influence on inflammation and immune regulation.
Key words: hydrogen sulfide; immune regulation; lymphocyte; neutrophil; macrophage