《生命科学》 2010, 22(10): 1005-1108

端粒酶线粒体转位

文　蕾，凌贤龙*

(第三军医大学新桥医院消化科，重庆 400038)

摘　要：

摘　要：端粒酶是一种逆转录酶，主要存在于细胞核，其主要功能是维持端粒长度，有助于细胞永生化。现已发现，氧化应激可以改变端粒酶活性，促使端粒酶从细胞核转位到线粒体，因而不能继续维持端粒长度，使细胞端粒缩短。端粒酶线粒体转位的非依赖端粒功能包括改善线粒体功能、减少细胞氧化应激、拮抗细胞凋亡。
关键词：端粒酶；线粒体转位；端粒酶的非依赖端粒功能
中图分类号：R363;Q55    文献标识码：A

    

 

Translocation of telomerase to mitochondria

WEN Lei， LING Xian-long*

(Department of Gastroenterology，Xinqiao Hospital， The Third Military Medical University， Chongqing 400038， China)

Abstract: Abstract：Telomerase is a reverse transcriptase which main exist in nucleus，with the main function of maintaining telomeres，so it contributes to cellular immortality . It has been demonstrated that telomerase activity would be altered upon oxidative stress and excepted from nucleolus to mitochondria as well as telomere shortening. The telomere-independent functions of translocation of telomerase to mitochondria have been related to improved mitochondrial function， decreased oxidative stress and resistaned cell apoptosis.
Key words：Telomerase; translocation to mitochondria; telomere-independent functions of telomerase.