《生命科学》 2010, 22(10): 1000-1004

脑啡肽基因多态性与阿尔茨海默病的文献综合分析

徐珊瑚，舒勤奋，周育苗，倪姣娜*

(浙江医院神经内科，杭州310012)

摘　要：
    

摘　要：阿尔茨海默病(Alzheimer抯 disease， AD)是痴呆最常见的类型，以记忆减退、认知障碍和行为异常为主要临床表现，可能与遗传和环境因素有关。研究认为b淀粉样蛋白肽(amyloid beta， Ab)的蓄积是AD发病的中心环节。脑啡肽(Neprilysin， NEP)作为脑内Ab的主要降解酶，是AD研究的热点。现阶段关于NEP基因多态性和AD发病的关联研究颇多，但尚未证实两者间的关系，存在许多不一致的结论。该文利用文献检索系统，对NEP基因多态性与AD临床相关性的文献进行检索分析，了解目前研究现状，分析可能造成的原因，探索进一步的研究方案。
关键词：脑啡肽；阿尔茨海默病；基因多态性；文献分析
中图分类号：R749.16; R592.1; G353.11  文献标志码：A

The association between neprilysin polymorphisms and Alzheimer’s disease: a literature analysis

XU Shan-hu， SHU Qin-fen， ZHOU Yu-miao， NI Jiao-na*

(Department of Neurology， Zhejiang Hospital， Hangzhou 310012， China)

Abstract: Abstract：Alzheimer{$39}s disease (AD) is the most common form of dementia. Memory impairment， cognitive impairment and abnormal behavior are the common recognized symptoms. The cause and progression of the disease are not well understood. Researches indicated that the deposition of amyloid beta (Ab) peptide plays a central role in the development of AD. As one of the main enzyme in amyloid beta degradation， Neprilysin (NEP) is a hot candidate gene for AD. There were several genetic studies have been published about the association of neprilysin polymorphism and AD， but with controversial results. Here， we present the recent studies worldwide on NEP polymorphisms and AD， analyse the present condition and discuss the possible reasons for better further research.
Key words：neprilysin; Alzheimer{$39}s disease; gene polymorphism; literature analysis