《生命科学》 2010, 22(10): 995-999

室管膜下区神经干细胞与神经发生的研究进展

惠董娜，王晓雯，王　念，吴民耀*

(陕西师范大学生命科学学院，西北濒危药材资源开发国家工程实验室，西安710062)

摘　要：

摘　要：室管膜下区(subventricular zone， SVZ)存在着神经干细胞(nueral stem cells， NSCs)，是成年哺乳动物脑内重要的神经发生区域。神经发生过程极为复杂，包括一系列的生物学事件。在病理状态下，SVZ区的细胞增殖，新生的神经细胞迁移到病灶处，取代或修复受损的细胞，起到保护脑组织的作用。该文就SVZ区的神经干细胞、神经发生过程及病理状态下神经发生的相关研究做一综述。
关键词：室管膜下区；神经干细胞；神经发生
中图分类号：Q426;R338.2    文献标识码：A

Recent research on neural stem cells and neurogenesis of subventricular zone

HUI Dong-na， WANG Xiao-wen， WANG Nian， WU Min-yao

(National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China， College of Life Science， Shaanxi Normal University， Xi{$39}an 7100062， China)

Abstract:

Abstract: Neural stem cells persist in the subventricular zone， which is a main area of neurogenesis in adult mammalian brain. The process of neurogenesis is extremely complex， including a series of biological events. Under the pathological conditions， the cells in subependymal zone can proliferate and newborn neurons migrate to the lesions， where they replace or repair the damaged cells， playing a role in protecting brain. Here， after describing the neural stem cells and its character， we review recent advances in the process of neurogenesis in subependymal zone and its changes in pathological states.
Key words: subventricular zone; neural stem cell; neurogenesis