《生命科学》 2010, 22(10): 991-994

分子伴侣介导的细胞自噬作用机制及其功能

席兴字

(新乡学院教育科学系，新乡453007)

摘　要：摘　要：分子伴侣介导的细胞自噬(chaperone-mediated autophagy， CMA)是通过溶酶体途径选择性降解胞质中带KFERQ-序列的蛋白质。CMA不仅为细胞在持久饥饿状态下提供能量，还在氧化性损伤保护、维持细胞内环境稳态等方面发挥作用。此外，CMA功能障碍还与某些疾病的发生有关。该文简要综述了这方面的研究进展。
关键词：分子伴侣；自噬；热休克蛋白70；溶酶体
中图分类号：Q255  文献标识码：A

The mechanisms and functions of chaperone-mediated autophagy

XI Xing-zi

(College of Education Science， Xinxiang University， Xinxiang 453007， China)

Abstract:

Abstract: Chaperone-mediated autophagy (CMA) is selective lysosomal pathway for the degradation of cytosolic proteins containing the KFERQ-related motif. CMA not only provides energy for cells during prolonged starvation， but also plays key roles in oxidative stress and cellular homeostasis. In addition， CMA dysfunction is of relevance in certain pathologies. This paper summarizes the recent research progress in CMA.
Key words: chaperone; autophagy; heat shock cognate protein 70; lysosome