《生命科学》 2010, 22(10): 978-984

MAPK信号途径及其在水生无脊椎动物的研究进展

马阿妮1，王艺磊1*，张子平2，韩坤煌1

(1 集美大学水产学院，福建省高校水产科学技术与食品安全重点实验室， 厦门 361021； 2德克萨斯州立大学化学和生物化学系，美国圣马克斯)

摘　要：摘　要：丝裂原活化蛋白激酶(mitogen-activatived protein kinase，  MAPK)信号转导途径普遍存在于真核生物，广泛参与细胞生长、分化、生殖、凋亡、应激等多种生理过程。它通过保守的三级激酶级联反应将细胞外信号传递到细胞内，磷酸化底物蛋白或转录因子发挥作用。目前，MAPK途径在哺乳动物的作用机制，尤其是该途径与人类疾病的关系已有大量的研究，但对水生无脊椎动物的研究相对较少。该文综述了目前MAPK在水生无脊椎动物的研究进展，并对今后的研究方向提出建议。
关键词：丝裂原活化蛋白激酶；信号转导途径；水生无脊椎动物
中图分类号：R329.2; Q859.132    文献标识码：A

MAPK signal transduction pathway and it’s research advance in aquatic invertebrates

MA A-ni1， WANG Yi-lei1* ZHANG Zi-ping2 HAN Kun-huang1

( 1 The Key Laboratory of Science and Technology for Aquaculture and Food Safety， Fisheries College ， Jimei University ， Xiamen 361021 ， China ; 2 Department of Chemistry and Biochemistry， Texas State University， San Marcos TX 78666， USA )

Abstract: Abstract: Mitogen-activated protein kinase (MAPK) signal transduction pathway exists in all eukaryotic cells involved widely in cell growth， differentiation， reproduction， apoptosis， anti-stress and other physiological processes. It transducts signals from outside to the cytoplasm or nucleus by a conserved three-kinase cascade， phosphorylating intracellular substrate proteins or transcription factors to regulate physiological processes. Currently， most of the knowledge about the mechanisms of the MAPK pathway focuses on the mammalian system， with an emphasis on its relationship to human disease and the pathway. So far basic knowledge of the MAPK pathway in aquatic invertebrates is limited. In this article， combined data collected in our laboratory， we review the research advance on MAPK pathway in aquatic invertebrates to date and propose future development to the field.
Key word: Mitogen-activated protein kinase；signal transduction pathway; aquatic invertebrate