《生命科学》 2010, 22(10): 965-970

胰高血糖素样肽-1及其类似物抗胰岛b细胞凋亡作用及机制的研究进展

高炜炜，王明伟*

(中国科学院上海药物研究所，国家新药筛选中心，上海201203)

摘　要：摘　要：胰高血糖素样肽-1(glucagon-like peptide-1， GLP-1)及其类似物通过提高增殖、减少凋亡， 从而有效地保护b细胞数量及功能。该文综述了GLP-1及其类似物能够对抗引起b细胞凋亡的多种有害因素——如细胞因子(IL-1b、TNF-a和IFN-g等)、高游离脂肪酸血症、高血糖或低血糖等——进而降低胰岛b细胞的凋亡率，并探讨了相关的作用机制。
关键词：胰高血糖素样肽1；胰岛b细胞；凋亡
中图分类号：R587.1; R977.15    文献标识码：A

Effects and mechanisms of glucagon like peptide-1(GLP-1) and its mimetics on the apoptosis of b cells

GAO Wei-wei， WANG Ming-wei*

(The National Center for Drug Screening， Shanghai Institute of Materia Medica， Chinses Academy of Sciences， Shanghai 201203， China)

Abstract: Abstract: Glucagon-like peptide-1(GLP-1) and its mimetic exhibit positive effects on b cell mass by both inceasing proliferation and decreasing apoptosis. Here we review the effects of GLP-1 and its mimetics on apoptosis caused by increased cytokines， glucose inbalance and lipotoxicity shown in both type 1 and type 2 diabetes. Studies in rodents， cell lines and isolated b cells are also analyzed in order to understand the mechanisms associated with the effects.
Key words: glucagon like peptide-1; b-cells; apoptosis