《生命科学》 2010, 22(10): 959-964

PIAS蛋白家族的研究进展

张露萍， 马　彬， 郑　英*

扬州大学医学院，扬州 225001

摘　要：摘　要：PIAS(protein inhibitor of activated STAT)蛋白家族是一种能够激活STAT转录活性的抑制蛋白，共包括4个成员，可与多种蛋白发生相互作用，从而影响靶蛋白的活性和功能，其主要与STAT、Wnt、TGF-b、NF-kB等通路的转录因子或转录辅因子相互作用以调控下游基因的转录活性。在细胞周期中，PIAS蛋白是细胞衰老和细胞凋亡的调节子，可促进细胞的扩散和衰老。在肿瘤发生中，PIAS蛋白的过表达能抑制癌细胞的增殖并诱导其凋亡。除此之外，在生殖系统和神经系统中，PIAS家族蛋白也能通过与相关的转录因子或激素受体相互作用影响其发生发展的过程。
关键词：PIAS蛋白；转录调控；生殖系统；细胞周期；细胞凋亡
中图分类号：Q71  文献标志码：A

The development of the protein inhibitor of activated STAT

ZHANG Lu-ping， MA Bin， ZHENG Ying*

(School of Medicine， Yangzhou University， Yangzhou 225001， China)

Abstract: Abstract: PIAS family is a protein inhibitor of activated STAT and contain four members， which could interact with many proteins and affect the activity and function of those proteins. PIAS mainly interacts with transcription factors or transcription cofactors of STAT， Wnt， TGF-b， NF-kB pathway to regulate transcriptional activity of target genes downstream. In mitotic cycle， PIAS adjusts cell senescence and cell perish， which can promote cell proliferation and senile. In tumor， overexpression of PIAS can inhibit the proliferation of cancer cells and induce cell apoptosis. Apart from this， in the reproductive system and nervous system， PIAS family proteins which interact with related transcription factors or hormone receptors can also affect the process of its occurrence and development.
Key words: PIAS proteins; transcriptional regulation; reproductive system; cell cycle; apoptosis