《生命科学》 2010, 22(9): 941-945

表面等离子体共振技术在药物研究中的应用

申刚义*，高　妍，刘　越，佘东来，谷雨龙，崔　箭

(中央民族大学中国少数民族传统医学研究院， 中国少数民族传统医学教育部重点实验室，北京 100081)

摘　要：摘　要：表面等离子体共振(surface plasmon resonance， SPR)技术作为一种新型的免标记、实时在线研究生物分子间相互作用的高灵敏传感技术，已经在生命科学领域中得到了大量应用。该文简要介绍了SPR生物传感器的基本原理，重点评述了其在新药筛选和药物作用机制方面的研究进展，并对其前景进行了展望。
关键词：表面等离子体共振；药物研究；进展

The application of surface plasmon resonance technology in drug research

SHEN Gang-yi*， GAO Yan， LIU Yue， SHE Dong-lai， GU Yu-long， CUI Jian

(Key Laboratory of Chinese Minority Traditional Medicine， Ministry of Education of China， Institute of Chinese Minority Traditional Medicine， Minzu University of China， Beijing 100081， China)

Abstract: Abstract: As a new label-free， real-time sensor technology with high sensitivity to research biomolecular interactions， surface plasmon resonance(SPR) has been widely used in the field of life science. In this review， the basic principle of SPR biosensor was introduced briefly， and its application in drug research including drug screening and the mechanism of drug action was also reviewed in detail.
Key words: surface plasmon resonance; drug research; review