《生命科学》 2010, 22(9): 930-940

阵列光镊与微流控芯片技术的结合与应用

李　勤*，李婧方

(北京理工大学生命学院生物医学工程系，北京100081)

摘　要：摘  要：在生物医学研究领域中，阵列光镊与微流控芯片的结合已经成为进行细胞操纵、转移以及少量细胞样品分选等方面最有希望的方法之一。光镊技术对样品具有非接触弹性控制、无机械损伤、可无菌操作等优势，以及微流控芯片分析的高效、多功能、微型化、低成本等优势，成为芯片实验室(Lab-on-a-Chip)的重要研究方面。该文概述了阵列光镊技术的形成与研究现状以及微流控芯片技术的发展与应用现状，分析了在不同阵列光镊形成方法下结合微流控芯片可实现的功能与应用，并对其发展趋势进行了展望。
关键词：阵列光镊；微流控芯片；微粒分选

Combination of optical tweezers array and microfluidic chips and its application

LI Qin*， LI Jing-fang

(Department of Biomedical Engineering， School of Life Science， Beijing Institute of Technology， Beijing 100081， China)

Abstract: Abstract: In the field of biomedical science， the combination of optical tweezers array and microfluidic chips has become a promising approach of cell manipulation， transportation and sorting. The advantages of optical tweezers technology are increasingly prominent. It can carry out flexible non-contact control， non-mechanical damage， and aseptic manipulation on samples， while microfluidic chips have the advantages of high-performance， multi-functional， miniaturized and cost-effective. The combination of them will be an important research area of Lab-on-a-Chip. This article provides an overview of recent research achievements and applications of optical tweezers array and microfluidic chips. Furthermore， the principles and functions for each formation of combination are analyzed. Finally， its applications on biological scientific research and further developments are described briefly.
Key words: optical tweezers array; microfluidic chips; particle sorting