《生命科学》 2010, 22(9): 906-912

g-分泌酶组件蛋白Nicastrin的研究进展

龙志敏，贺桂琼*

(重庆医科大学神经科学研究中心，人体解剖教研室，重庆 400016)

摘　要：摘　要：Nicastrin(NCT)是高度糖基化的I型跨膜蛋白，是g-分泌酶复合物的重要组件蛋白之一，广泛分布于人类或鼠的所有细胞类型。它不仅与g-分泌酶的组装和成熟密切相关，其构象及表达变化对g-分泌酶活性和阿尔茨海默病(Alzheimer抯 disease， AD)中b淀粉样蛋白(amyloid protein b， Ab)的产生及降解也起重要调节作用。本文就国际上近几年在NCT的结构、合成、分布、降解及功能等方面的研究进展作一综述。
关键词：Nicastrin；g-分泌酶；b淀粉样蛋白；阿尔茨海默病

Progress in the research on Nicastrin， one of essential subunits of g -secretase

LONG Zhi-min， HE Gui-qiong*

(Department of Anatomy， Institute of Neuroscience， Chongqing Medical University， Chongqing 400016， China)

Abstract: Abstract: Nicastrin(NCT)， one of the most important components of g-secretase， is a highly glycosylated type I transmembrane glycoprotein. It is expressed in almost all cell types in human and mouse. NCT is not only closely related to the assembly and maturation of g-secretase complex， more importantly， changes of its conformation and expression have a significant effect on the regulation of g-secretase activity， as well as the generation and degradation of amyloid b peptide in Alzheimer抯 disease. This review summarizes the development of structure， synthesis， distribution， degradation and function of NCT in recent years， including that in our laboratory.
Key words: nicastrin; g-secretase; amyloid b peptide; Alzheimer抯 disease