《生命科学》 2010, 22(9): 886-895

LuxR家族调控蛋白的结构及功能

郑世超1，罗 瑛1，鲁 涛2*

(1 昆明理工大学生命科学与技术学院，衰老与肿瘤分子遗传学实验室，昆明 650224 ；2云南大学，云南省微生物研究所，昆明 650091)

摘　要：摘　要：LuxR家族调控蛋白是一类在革兰氏阴性细菌群体感应中起重要作用的调控蛋白，它们参与由酰基高丝氨酸内酯介导的多种生物学过程，调控细菌生物发光、质粒转移、生物膜形成以及多种胞外酶、毒力因子和次生代谢产物的合成。LuxR家族蛋白的研究在医学、环境监测、生物防治和微生物发酵等方面具有巨大的应用潜力。该文综述了LuxR家族调控蛋白近期的研究进展、存在问题及应用前景。
关键词：LuxR；调控蛋白；群体感应

The structure and function of LuxR-family regulators

ZHENG Shi-chao1， LUO Ying1， LU Tao2*

(1 Laboratory of Molecular Genetics of Aging and Tumor， Faculty of Life Science and Technology， Kunming University of Science and Technology， Kunming 650224， China; 2 Yunnan Institute of Microbiology， Yunnan University， Kunming 650091， China)

Abstract: Abstract: The LuxR-family regulators play important roles in acyl-homoserine lactones-mediated quorum sensing in Gram-negative bacteria， regulating many bacterial physiological processes such as bioluminescence， plasmid transfer， biofilm formation， and the production of extracellular enzymes， virulence factors， and secondary metabolites. LuxR protein-related studies have huge application potential in medicine， environmental monitoring， biocontrol， and microbial fermentation. Herein we reviewed the recent progress in the research on LuxR-family proteins， remaining questions， and the perspectives of their application.
Key words: LuxR; regulator; quorum sensing