《生命科学》 2007, 19(1):

小胶质细胞与早老性痴呆症脑内炎症

代玉桥¹，金道忠²，雷德亮^1*

1中南大学湘雅医学院人体解剖学与神经生物学系，长沙 410013;2 中国科学院上海生命科学研究院上海药物研究所，上海 201203

摘　要：摘　要：早老性痴呆患者脑内存在炎症反应已被越来越多的证据支持。作为脑内的主要免疫细胞，小胶质细胞在中枢神经系统炎症过程中被过度激活，表达或释放细胞因子和炎症介质，是早老性痴呆发生发展的重要因素。抑制小胶质细胞激活、缓解炎症损伤，对延缓早老性痴呆的发展具有重要的的意义。
关键词：早老性痴呆；小胶质细胞；炎症

Microglia and inflammation in Alzheimer’s disease

DAI Yuqiao¹, JIN Daozhong², LEI Deliang^1*

1 Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China; 2 Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203,

Abstract: Abstract: Accumulating data evidenced inflammation involved in Alzheimer{$39}s disease (AD). Microglia, one of the main immune cells in central nerve system, was activated in inflammation with morphological changes from resting ramified to staffed and amoeboid cells. Moreover, toxic cytokines and inflammatory mediators were released, which exerted a series of influence on adjacent tissue. Inhibiting the microglia activation to attenuate inflammatory damage will be an important strategy to prevent the further deterioration in AD.
Key words: Alzheimer{$39}s disease; microglia; inflammation