《生命科学》 2010, 22(8): 793-796

多发性骨髓瘤中NF-kB作用机制研究

李　江，胡维新*

(中南大学生物科学与技术学院分子生物研究中心，长沙 410078)

摘　要：摘  要：多发性骨髓瘤(multiple myeloma， MM)是浆细胞异常增生的恶性肿瘤，其发病机制比较复杂。研究表明，活化NF-kB具有多种生物学功能，它既能调节细胞因子；影响细胞周期，又与血管发生有关，并且与多发性骨髓瘤治疗密切相关。该文就NF-kB在多发性骨髓瘤中的作用机制做一综述。  
关键词：多发性骨髓瘤；NF-kB；细胞因子；细胞周期；治疗

The progress of NF-kB mechanism research in multiple myeloma

LI Jiang， HU Wei-xin*

(Institute of Molecular Biology， School of Biological Science and Technology， Central South University， Changsha 410078， China)

Abstract: Abstract: Multiple myeloma (multiple myeloma， MM) is the abnormal proliferation of malignant plasma cells. Its pathogenesis is complex. The results show that activation of NF-kB has a variety of biological functions， both regulating cell factors， cell cycle， angiogenesis and closely relating with treatment of multiple myeloma. Now， a review of the progress of NF-kB mechanism in multiple myeloma was made in this article.
Key words: multiple myeloma; NF-kB; cytokines; cell cycle; treatment