《生命科学》 2010, 22(8): 783-787

巨核细胞生成调控相关细胞因子及其作用研究进展

陈石磊，王军平*

(第三军医大学军事预防医学院全军复合伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆 400038)

摘　要：摘　要：造血干细胞分化生成巨核细胞是一个十分复杂的过程，包括造血干细胞动员及其向巨核系祖细胞分化，巨核系祖细胞增殖、分化生成未成熟巨核细胞，巨核细胞的成熟和血小板释放等过程。研究发现，造血干细胞动员及其向各系细胞分化的大部分过程都在一种称为“龛”的结构中进行，多种龛内信号分子参与了造血干细胞的动员和分化调控。该文对造血干细胞龛内参与造血干细胞动员和分化生成巨核细胞的几种重要细胞因子及其调控作用进行综述。
关键词：造血干细胞；龛；巨核细胞生成；细胞因子；调控

Relative cytokines and their regulatory roles in megakaryocytopoiesis

CHEN Shi-lei， WANG Jun-ping*

(State Key Laboratory of Trauma， Burns and Combined Injury， Institute of Combined Injury， College of Preventive Medicine， Third Military Medical University， Chongqing 400038， China)

Abstract: Abstract: It is a quite complex process that hematopoietic stem cells differentiate into megakaryocytes， which is composed of the mobilization of hematopoietic stem cell and differentiation into megakaryocyte progenitor cells， the proliferation of megakaryocyte progenitor cell， generation of mature megakaryocytes， megakaryocyte maturation and platelet release etc. It has been found that the mobilization of hematopoietic stem cell and the differentiation into most lineages are in a structure called "niche“.? A variety of signaling molecules involved in the regulation of hematopoietic stem cell mobilization and differentiation. This review is focus on several important cytokines participating in hematopoietic stem cell mobilization and megakaryocytopoiesis and their regulatory role in the niche.
Key words: hematopoietic stem cell; niche; megakaryocytopoiesis; cytokines; regulation