《生命科学》 2010, 22(8): 778-782

产白介素-17 T细胞在肺部细菌感染中的研究进展

刘嘉琳，李庆云，万欢英*

(上海交通大学医学院附属瑞金医院呼吸科，上海200025)

摘　要：摘　要：目前产白介素-17(IL-17)T细胞主要包括了产IL-17 CD4+ T细胞即Th17细胞、产IL-17 gd T细胞和产IL-17 CD8+ T细胞等。随着对Th17这一系细胞功能研究的不断深入，发现它们能通过产生IL-17和IL-22等细胞因子参与炎症反应。该文将对产IL-17 T细胞在肺部细菌感染中所起作用的最近研究进展进行综述。
关键词：产白介素-17 T细胞；肺部细菌；感染免疫

Reseach progress on IL-17-producing T cells and pulmonary bacterial infection

LIU Jia-lin， LI Qing-yun， WAN Huan-ying*

(Department of Pulmonary， Ruijin Hospital， School of Medicine， Shanghai Jiao Tong University， Shanghai 200025， China)

Abstract: Abstract: Interleukin-17 is a proinflammatory cytokine that is produced by a variety of cells， including a newly identified subset of activated CD4+ T cells (Th17 cells)， gd T cells， CD8+ cells and NKT cells. Th17 cells are thought to be a distinct lineage of Th cells that mainly produce IL-17， IL-22 and other cytokines which are involved in inflammatory response. gd T cells have also been shown to be a potent source of IL-17 and， in some cases， produce more IL-17 than ab T cells. IL-17-producing T cells are important in the host defense against acute pulmonary infection during the early immune response， also have the potential to elicit detrimental responses during chronic infection-related inflammatory conditions. This review will introduce recent research progress on the role of IL-17-producing T cells in the pulmonary bacterial infection.
Key words: IL-17-producing T cells; pulmonary bacterial; infection immunity