《生命科学》 2007, 19(1):

小胶质细胞与炎症介导的神经系统退行性病变

薛 旸^1,2， 李海峰³， 徐凌云^1,2*

1上海交通大学医学院 上海市免疫学研究所，上海 200025；2中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，上海 200025；3青岛大学医学院附属医院神经内科，青岛 266021

摘　要：摘　要：小胶质细胞是中枢神经系统常驻细胞，行使支持、营养、免疫监视等多种功能。小胶质细胞在受到感染、外伤等因素刺激后活化，并产生多种免疫效应分子，包括：白细胞介素、肿瘤坏死因子、干扰素g、活性氮、活性氧等。这些因子介导慢性炎症反应、细胞凋亡等，是导致神经系统退行性病变的主要因素。本文着重阐述小胶质细胞通过分泌这些效应分子引起神经功能损伤的机制，并对目前一些针对性治疗方法加以介绍。
关键词：小胶质细胞；炎症；神经系统退行性病变

Microglia: in inflammation-mediated neurodegenerative diseases

XUE Yang^1,2, LI Haifeng³, XU Lingyun^1,2*

1 Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 2 Institute of Health Sciences, Shanghai Institues for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiaotong University Scho

Abstract: Abstract: Microglia are resident immune cells of the CNS, which play the roles of sustaining, nourishing and immune surveillance. In the case of stimuli occurring such as infection and trauma, microglia become activated, and then they produce many immune effector molecules, including interleukin, tumor necrosis factor, interferon -g, reactive nitrogen species, reactive oxygen species, etc. These factors can mediate chronic inflammatory response, apoptosis, etc, which are the major reasons causing neurodegenerative diseases. In this article,  we try to illustrate the mechanism how neural function is damaged by the microglial effector molecules, and introduce some current therapeutic approaches at the present time.
Key words: microglia; inflammation; neurodegenerative diseases