《生命科学》 2010, 22(7): 703-709

mRNA出核转运及其偶联网络

迟斌凯，朱长兰，王庆亮，王兰甜，程　红*

中国科学院上海生命科学研究院生物化学与细胞生物学研究所，中国科学院分子生物学国家重点实验室，上海200031

摘　要：摘　要：真核细胞中，编码蛋白质基因的表达是一个复杂的、分步骤进行的过程，这个过程从转录和新生pre-mRNA的核内加工开始，经过正确加工的成熟mRNA从加工位点释放，出核转运后在细胞质内翻译成蛋白质。mRNA出核转运是基因表达中的关键步骤，由进化上高度保守的特定蛋白质介导完成。mRNA出核与转录和mRNA加工步骤密切偶联，这样的偶联可以提高基因表达的有效性和准确性。
关键词：mRNA出核；偶联；基因表达；TREX

mRNA export and its coupling in gene expression

CHI Bin-kai， ZHU Chang-lan， WANG Qing-liang， WANG Lan-tian， CHENG Hong*

State Key Laboratory of Molecular Biology， Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China

Abstract: Abstract：In eukaryotes， the expression of protein-coding genes is a complex stepwise process， which begins with transcription and processing of nascent transcripts in the nucleus. Upon maturation， the mature mRNAs are then released from the processing site and exported into the cytoplasm for translation into proteins. mRNA export is a critical step in gene expression， which involves a specific cellular machinery that is highly conserved from yeast to humans. mRNA export is coupled to transcription and mRNA processing steps， and this extensive coupling may enhance the efficiency and fidelity of gene expression.
Key words: mRNA export; coupling; gene expression; TREX