《生命科学》 2010, 22(7): 655-660

循环血中microRNAs作为疾病标志物的研究进展

朱嘉琦1，王国坤1，2，秦永文1，荆　清1，2*

1上海长海医院心内科， 上海200433； 2中国科学院上海生命科学研究院健康科学研究所，上海200025

摘　要：摘　要：新近研究发现成熟的microRNA能够游离于细胞之外，稳定存在于循环血中，具备疾病分子生物标志物的某些优点，已在多种肿瘤和非肿瘤疾病的早期诊断和预后中显示了独特的价值，同时循环血中microRNA的功能研究也已开始。该文针对近两年循环血中microRNA标志物及功能研究的成果，对microRNA研究中的这一热点问题进行综述。
关键词：循环血；microRNA；标志物

Advances of circulating microRNAs as a novel biomarker for diseases

ZHU Jia-qi1， WANG Guo-kun1，2， QIN Yong-wen1， JING Qing1，2*

1 Changhai Hospital， Shanghai 200433， China; 2 Institute of Health Sciences， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200025， China

Abstract: Abstract：Cell free microRNAs have been found the be present in circulation recently， and displayed some characteristics of an ideal biomarker. Furthermore， circulating microRNAs have been verified and applied in diagnosis and prognosis of cancers and many other diseases. The study on function of circulating microRNAs has been put on agenda. This paper aimed to review the new findings in the field of circulating microRNAs as a novel biomarker for diseases.
Key words：circulation; microRNA; biomarker