摘 要：摘 要：Raf激酶抑制蛋白（Raf kinase inhibitor protein，RKIP）属于磷脂酰乙醇胺结合蛋白（phosphatidylethanolamine-binding protein, PEBP）家族，广泛存在于各种生物中，参与了对细胞内多种信号转导通路的调节作用。RKIP可以与Raf-1结合，从而抑制MAPK信号转导通路，并参与了对G蛋白偶联受体信号通路和NF-κB信号通路的调控。RKIP在膜的生物合成、精子发生、神经发育和细胞凋亡等生理过程中发挥重要作用，并参与了老年痴呆症及糖尿病等的病理过程。此外，近年来的研究表明RKIP是一个新的转移抑制因子，可以抑制前列腺癌、人乳腺癌和黑色素瘤细胞的转移，并已成为一个新的前列腺癌诊断标志物。
关键词：Raf激酶抑制蛋白; 信号转导; 前列腺癌; 转移; 细胞凋亡
Abstract: Abstract: Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine -binding protein(PEBP) family, which is a widely expressed protein in a variety of different species. It plays a pivotal modulatory role in several intracellular signaling cascades. RKIP binds to Raf-1, and blocks MAPK signaling pathway. Also it has been demonstrated to regulate G-protein-coupled receptor signaling pathway and NF-κB signaling . RKIP plays a critical role in several physiological processes including membrane biosynthesis, spermatogenesis,neural development and apoptosis. It also contributes to pathophysiological processes including Alzheimer{$39}s disease and diabetic nephropathy. Additionally, recent researches show RKIP is a novel metastasis suppressor,which suppresses metastasis in prostate cancer, breast cancer and melanoma cancer. And RKIP becomes a novel prognostic marker in prostate cancer.
key words: RKIP; signal transduction; prostate cancer; metastasis; apoptosis
