《生命科学》 2010, 22(4): 377-381

TGF-b/Smad通路对造血干细胞的调控作用

张　恒， 王月英， 孟爱民^*

(中国医学科学院北京协和医学院放射医学研究所，天津市分子核医学重点实验室，天津 300192)

摘　要：摘  要：造血干细胞(hematopoietic stem cells， HSCs)是典型的成体干细胞，造血系统的稳定依靠造血干细胞正确的自我更新、增殖和分化。TGF-b超家族包括TGF-b、骨生成蛋白(BMP)和激活素，可通过Smad蛋白对造血干细胞进行调节。TGF-b/Smad通路可通过降低CDK4的表达、增加p21蛋白表达和改变p27分布，将造血干细胞阻断于G1期；通过上调CD34表达，抑制造血干细胞的分化。但也有不同的观点，认为TGF-b对HSCs的调节与Smads无关，TGF-b并非通过调控p21和p27抑制HSCs的增殖，TGF-b/Smad通路对维持HSCs静止状态无关。
关键词：造血干细胞；转化生长因子-b；Smads
中图分类号：Q813　　文献标识码：A

TGF-b/Smad signaling pathway regulates hematopoietic stem cells

ZHANG Heng， WANG Yue-ying， MENG Ai-min^*

(The Key Laboratory of Molecular Nuclear Medicine in Tianjin， Institute of Radiation Medicine， Peking Union Medical College， Chinese Academy of Medical Sciences， Tianjin 300192， China)

Abstract: Abstract: Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of adult stem cells， and homeostasis of the hematopoietic system is maintained by their accurate self renewal， proliferation and differentiation. The TGF-b family of ligands， including TGF-b， bone morphogenetic protein (BMP) and activin， signal through Smad pathways to regulate the fate of hematopoietic stem cells. TGF-b/Smad pathway may cause transcriptional activation of CD34 and preserve haematopoietic stem/progenitor cells activity . Also， the pathway may be involved in HSCs?G1 arrest by down-regulating CDK4， up-regulating p21 and redistributing p27. However， there are some conflicting opinions as whether TGF-b regulates HSCs through Smads， whether TGF-b inhibits proliferation of HSCs by p21/p27， and whether the pathway is a control device of HSCs{$39} fate， et al.
Key words: haemopoietic stem cells; transforming growth factor-b; Smads