《生命科学》 2010, 22(4): 317-320

SIRT1与神经变性疾病

王　颖¹，高　静²，钱进军^1*

(1 江苏大学附属第四人民医院，镇江212001；2江苏大学药学院，镇江212001)

摘　要：摘　要：SIRT1 (silent mating type information regulation 2 homolog 1)是Sirtuins脱乙酰基酶家族中的一员，是酵母沉默信息调节因子SIR 2(silence information regulator)的同源物，因其能在许多生物体模型中作为寿命延长调节子调控细胞生命周期而受到特别关注。SIRT1蛋白存在于哺乳动物细胞质和细胞核中，是老化相关蛋白。SIRT1作用于基因转录因子能加强基因组的稳定性。神经系统发生变性疾病时SIRT1表达量上调，起到一定的神经保护作用。但有实验验证神经元损伤SIRT1过表达导致记忆缺失，并没有起到神经保护作用。SIRT1诱导剂，可以是Sirtuin的激动剂也可以是能量限制状态。目前在生命科学领域里SIRT1已经凸显其科学价值地位，该文就SIRT1及其与神经变性疾病之间的关系做一综述。
关键词：SIRT1；神经变性疾病；脱乙酰基酶
中图分类号：R741; Q51   文献标识码：A

SIRT1 and neurodegenerative diseases

WANG Ying¹， GAO Jing²， QIAN Jin-jun^1*

(1 Affiliated NO.4 People{$39}s Hospital of Jiangsu University， Zhenjiang 212001， China; 2 College of Pharmacy， Jiangsu University， Zhenjiang 212001， China)

Abstract: Abstract: Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuins family of protein deacetylases， the homologue of yeast silent information regulator (SIR)-2， which have gained much attention as mediators of lifespan extension in several model organisms. SIRT1-protein is localized both in the nucleus and cytoplasm of mammalian as a kind of anti-aging protein. The gene transcription factors are regulated by SIRT1 which could enhance the stability of genome. SIRT1，whose expression upregulation is observed in neurodegenerative diseases， have a role in neuroprotection. But there is another article demonstrating that overexpression of SIRT1 did not have any neuroprotective effects against the neuronal damage， showing a reference memory deficit. SIRT1 can be induced by sirtuin activators or by metabolic conditioning associated with caloric restriction (CR). At present， SIRT1 exhibit its scientific value in the field of life science. In this review we summarize the role of SIRT1 and the relationship between SIRT1 and neurodegenerative disease.
Key words: SIRT1; neurodegenerative disease; histone deacetylase