《生命科学》 2010, 22(6): 579-582

巨噬源性泡沫细胞形成过程中的机理研究及其进展

周　云，沃兴德*

(浙江中医药大学生命科学学院，杭州310053)

摘　要：摘　要： 巨噬源性泡沫细胞的形成是动脉粥样病变的关键环节，清道夫受体与胆固醇代谢相关受体在此过程中发挥极其重要的作用。下面就泡沫细胞形成过程中的关键因素及机理做如下综述，并探讨通过调节这些潜在因素和机理，开发靶向药物治疗方法，有效抑制动脉粥样硬化的发生发展。
关键词： 巨噬细胞；清道夫受体；酰基辅酶A：胆固醇酰基转移酶（ACAT）；ATP结合盒转运子 AI (ABCA1); 胆固醇酯转运蛋白(CETP)
中图分类号：Q555+.3   文献标识码：A

The mechanism research of the macrophage-derived foam cell formation and its progress

ZHOU Yun， WO Xing-de*

(College of Life Science， Zhejiang Traditional Chinese Medicine， Hangzhou 310053， China)

Abstract: Abstract:  The formation of macrophage derived foam cells is a key link to atherosclerotic lesions，Scavenger Receptors and other relative receptors in cholesterol metabolism play an important role in this process. The following review is on the key factors and mechanisms of foam cells formation，and discuss the potential by modulating these factors and mechanisms， in order to develop targets-specific therapeutics for efficient treatment of atherosclerosis.
Key words:  macrophage; scavenger receptor; ACAT; ABCA1;CETP