《生命科学》 2010, 22(6): 575-578

DNA断裂因子相似蛋白(CIDE)家族在甘油三酯代谢中的作用

向梳瑕，潘志雄，李 亮，王继文*

（四川农业大学畜禽品种资源发掘与利用重点实验室，雅安 625014）

摘　要：摘　要:  DNA断裂因子相似蛋白(cell-death-inducing DNA-fragmentation-factor-like effector， CIDE)家族包括三个成员：CIDE-A、CIDE-B和CIDE-C。小鼠中CIDE-C被称为脂肪特异性蛋白27(fat special protein 27，FSP27)，以前都作为细胞凋亡因子加以研究。近年来研究显示，敲除了CIDE-A、CIDE-B、FSP27的动物都表现出了能量释放增多，且能够抵抗食物导致的肥胖以及对胰岛素敏感性增强。CIDE家族定位于内质网、脂滴和线粒体，参与甘油三酯储存、降解以及分泌代谢，与肥胖、高血脂、糖尿病、脂肪肝等脂类代谢相关疾病也有着密切关系，在调控机体脂质代谢平衡方面扮演着重要的角色。该文对CIDE家族在甘油三酯代谢方面的作用及其调控的分子机制进行综述。
关键词：甘油三酯/三酰甘油；DNA断裂因子相似蛋白A；DNA断裂因子相似蛋白B；DNA断裂因子相似蛋白C/脂肪特异性蛋白27
中图分类号：Q71 文献标识码：A

The role of cell-death-inducing DNA-fragmentation-factor-like effector (CIDE) family in TG metabolism

XIANG Shu-xia， PAN Zhi-xiong， LI Liang， WANG Ji-wen *

(Key Laboratory of Animal Genetic Resources Exploitation and Utilization， Sichuan Agricultural University， Ya抋n 625014， China)

Abstract: Abstract: The CIDE (cell-death-inducing DNA-fragmentation-factor-like effector) family proteins， comprising three members， CIDE-A， CIDE-B and CIDE-C， mouse CIDE-C is known as FSP27 (fat special protein 27). Recent studies have shown that animals with deficiency in CIDE-A， CIDE-B and FSP27 all display lean phenotypes with higher energy expenditure and are resistant to diet-induced obesity and insulin resistance. CIDE family has an effect on triglyceride metabolism including triglyceride storage， degradation and secretion through localization on the surface of ER (endoplasmic reticulumlipid)， lipid droplets and mitochondria in adipocytes and hepatocytes. Though it was studied as a factor of apoptosis， it plays an important role on the balance of lipid metabolism and lipid metabolism- related diseases such as obesity， hyperlipemia， liver steatosis and insulin sensitivity. In this review， we introduced the study on CIDE family in triglyceride metabolism and the molecular mechanism of the regulation.
Key words: TG/TAG; CIDE-A; CIDE-B; CIDE-C/FSP27