《生命科学》 2010, 22(6): 546-550

动物TLR4基因多态性及其抗病相关性研究进展

贾红敏1，2，卢立志2，石放雄1，李国勤2*

(1南京农业大学动物科技学院， 南京 210095；2浙江省农科院畜牧兽医所， 杭州 310021)

摘　要：摘　要：TLR4是天然免疫系统中的一种重要模式识别受体，可选择性识别病原微生物而启动天然免疫，在宿主天然免疫和获得性免疫中具有重要作用。此外，大量研究表明，TLR4基因的多态性与多种动物的细菌、病毒和寄生虫性疾病密切相关，说明通过TLR4基因的研究可为动物分子标记辅助选育研究提供依据。该文简要论述部分动物TLR4基因多态性及其与抗病相关性的研究进展。
关键词：TLR4基因；多态性；抗病力；关系
中图分类号：S813.3　　文献标识码：A

Association of TLR4 polymorphisms with disease resistance traits in animals

JIA Hong-min1，2， LU Li-zhi2， SHI Fang-xiong1， LI Guo-qin2*

(1 College of Animal Science， Nanjing University of Agricultural Sciences， Nanjing 210095， China; 2 Institute of Animal Science and Veterinary Medicine， Zhejiang Academy of Agricultural Sciences， Hangzhou 310021， China)

Abstract: Abstract: TLR4 is an important pattern recognition receptor in the natural immune system， which can activate innate immunity by selectively identifying pathogenic microorganisms and plays an important role in the innate immunity and acquired immunity. According to a lot of researches， the genetic polymorphisms of TLR4 are closely related to a variety of diseases in animals， suggesting that it can provide plenty of information for animal molecular marker-assisted breeding. More  information about the polymorphisms of TLR4 gene and their relationships with disease resistance traits in some animals will be introduced briefly in this paper.
Key words: TLR4; polymorphism; disease resistance trait; relationship