《生命科学》 2010, 22(6): 534-538

Th17细胞分化和功能的研究进展

郑钰涵， 吴晓东， 孙　兵*

(中国科学院上海生命科学研究院生物化学与细胞生物学研究所，上海200031)

摘　要：摘　要：近年研究发现了效应性辅助性T细胞的新亚群-Th17细胞，它主要分泌IL-17、IL-17F、IL-21和IL-22等细胞因子。Th17细胞及其效应分子被认为与自身免疫病和其他多种疾病相关。该文从Th17细胞的发现、人和小鼠Th17细胞的分化、Th17细胞的效应性因子及与健康和疾病的相关性几个方面对目前的研究进展进行了综述。
关键词：Th17细胞；分化；细胞因子；自身免疫病；组织炎症
中图分类号：R392.12 文献标识码：A

The progress on differentiation and function of Th17 Cells

ZHENG Yu-han， WU Xiao-dong， SUN Bing*

(Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biology Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract：Th17 cells are a newly discovered subset of effector T helper cells，and mainly produce cytokines such as IL-17， IL-17F， IL-21and IL-22. Th17 cells and Th17-specific cytokines are thought to be associated with autoimmune disease and many other diseases. Here， we review the current progress of Th17 cells， including the discovery of Th17 cells， the differentiation of Th17 cells in both murine and human beings， Th17-specific cytokines and effector function with health and disease in detail.
Keywords：Th17 cells; differentiation; cytokines; autoimmunity; tissue inflammation