《生命科学》 2010, 22(6): 529-533

滤泡辅助性 T细胞分化和功能的研究进展

吴晓东，李振虎，孙　兵*

(中国科学院上海生命科学研究院生物化学与细胞生物学研究所，上海200031)

摘　要：摘　要：滤泡辅助性 T细胞(T follicular helper cells， TFH细胞)是新近发现的一种CD4+辅助性T细胞亚群，具有不同于其他亚群的独特功能：迁移到B淋巴滤泡并辅助B淋巴细胞产生抗体。在短短的几年里面，已有大量针对滤泡辅助性 T细胞分化与功能的研究。该文将对滤泡辅助性T细胞的最新研究进展作一综述。
关键词：滤泡辅助性 T细胞; 分化；体液免疫；抗体产生
中图分类号：Q257　　　文献标识码：A　

The progress on differentiation and function of T follicular helper cells

WU Xiao-dong， LI Zhen-hu， SUN Bing *

(Institute of Biochemistry and Cell Biology， Shanghai Intitutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: A newly identified subset of T cells， termed T follicular helper (TFH) cells ， has a unique ability to home to B cell follicles and to induce antibody production by B cells. In the past few years， there has been a surge of research aimed at understanding the function and differentiation of these important cells. This Review focuses on the current progress in TFH cell biology
Keywords：T follicular helper cells; differentiation; humoral immunity; antibody production