《生命科学》 2010, 22(5): 449-453

纤溶酶原在金黄色葡萄球菌感染中的作用

纪智星，韩润林^*

内蒙古农业大学血浆脂蛋白免疫学研究中心，呼和浩特 010018

摘　要：摘　要：金黄色葡萄球菌菌体表面有多种纤溶酶原受体，包括次黄嘌呤单核苷酸脱氢酶、核糖核苷酸还原酶、a-烯醇化酶和3-磷酸甘油醛脱氢酶等，它们均可以与纤溶酶原结合。与细菌结合的纤溶酶原可被宿主的纤溶酶原激活剂（组织型纤溶酶原激活剂和尿激酶型纤溶酶原激活剂）或葡萄菌属的纤溶酶原激活剂（葡激酶）激活为纤溶酶。细菌表面的纤溶酶有利于其降解宿主胞外基质，穿越组织屏障，因此哺乳动物的纤溶酶原可能在金黄色葡萄球菌感染宿主过程中起重要作用。
关键词：金黄色葡萄球菌；纤溶酶原；纤溶酶；受体

Plasminogen might be a virulence factor in Staphylococcus aureus infection

JI Zhi-xing， HAN Run-lin^*

Plasma Lipoprotein Immunology Research Center， Inner Mongolia Agriculture University， Huhhot 010018， China

Abstract: Abstract：Several plasminogen receptors (PlgR) have been identified on the surface of Staphylococcus aureus. These PlgRs include inosine 5{$39}-monophosphate dehydrogenase， ribonucleotide reductase， a-enolase and glyceraldehyde-3-phosphate dehydrogenase. S. aureus-bound Plg can be converted to plasmin by host plasminogen activator (PA) (tissue-type plasminogen activator and urokinase-type plasminogen activator) or staphylococcal PA (staphylokinase). Plasmin generated on bacterial surface enhances bacterial migration through the extracellular matrix (ECM) as well as spread through tissue barriers. Thus， plasminogen plays an important role in S. aureus infection.
Key words: Staphylococcus aureus; plasminogen; plasmin; receptor