《生命科学》 2010, 22(5): 444-448

CD44+CD24-/low与ALDH1+作为乳腺癌干细胞标志物之异同

韩明利¹，吴诚义^1*，王艺梦²

1 重庆医科大学附属第一医院内分泌外科，重庆 400016；2重庆医科大学附属第一医院急诊科，重庆 400016

摘　要：摘  要：越来越多的研究表明，CD44+CD24-/low与ALDH1+都是乳腺癌干细胞标志物。CD44+CD24-/low细胞与ALDH1+细胞具有很多相同的性质，但又有不同的性质和特点。该文主要就CD44+CD24-/low与ALDH1+之间的相同点、两者在乳腺癌干细胞特性方面的差异及其与乳腺癌基因亚型、预后、转移和耐药之间的不同关系等方面作一综述。
关键词：CD44；CD24；ALDH1；乳腺癌；肿瘤干细胞

comparison between CD44+CD24-/low and ALDH1+ as the markers of breast cancer stem cells

HAN Ming-li¹， WU Cheng-yi^1*， WANG Yi-meng²

1 Department of Endocrine Surgery， the First Affiliated Hospital of Chongqing Medical University， Chongqing 400016， China; 2 Department of Emergency， the First Affiliated Hospital of Chongqing Medical University， Chongqing 400016， China

Abstract: Abstract: Breast cancer cells that express CD44 +CD24-/low have been described as cancer stem cells(CSCs). Breast cancer cells expressing elevated levels of aldehyde dehydrogenase 1 (ALDH1) are also described as CSCs with ALDH1+CD44+CD24-/low subpopulation displaying highest tumorigenic potential in NOD/SCID models. CD44 +CD24-/low subpopulation and ALDH1+ subpopulation have many similarities， and also have many different properties and characteristics. Herein， we review and compare the available data reporting utilization of CD44+CD24-/low and ALDH1+ as the markers of breast cancer stem cells.
Key words: CD44; CD24; aldehyde dehydrogenase 1(ALDH1); breast cancer; cancer stem cells (CSCs)