《生命科学》 2010, 22(5): 426-430

神经元型一氧化氮合酶(nNOS)与疼痛

陈丽钦，洪炎国^*

福建师范大学生命科学学院，福州350108

摘　要：摘　要: 一氧化氮(NO)是神经元细胞内一种新型的神经递质，它由一氧化氮合酶(NOS)催化而成。在神经系统中神经元型一氧化氮合酶(nNOS)是NO合成的关键酶。大量研究表明，nNOS可调节多种生理和病理过程诸如炎性痛和神经病理性疼痛。该文通过介绍nNOS的结构、分布和影响nNOS活性的因素，阐述了nNOS在病理性疼痛中的重要作用，为此可通过调节nNOS表达来达到调节生理和病理过程。
关键词：神经元型一氧化氮合酶；一氧化氮；炎症痛；神经病理性疼痛

Neuronal nitric oxide synthase(nNOS) and pain

CHEN Li-qin， HONG Yan-guo^*

College of Life Science， Fujian Normal University， Fuzhou 350108， China

Abstract: Abstract: Nitric oxide (NO) acts as a new neurotransmitter in neuron cells. It is catalyzed by nitric oxide synthase (NOS). Neuronal nitric oxide synthase(nNOS)is a key enzyme for NO production. Accumulating evidence shows that nNOS is involved in modulating physiological and pathological process such as imflammatory pain and neuropathic pain. This review concentrates on nNOS structural features， subcellular localization and factors regulating nNOS function， expounds the of importance of nNOS in pathological pain. So， we can modulate physiological and pathological process through regulating nNOS expression.
Key words: neuronal nitric oxide synthase; nitric oxide; inflammatory pain; neuropathic pain