《生命科学》 2010, 22(5): 421-425

人参皂苷-Rh2诱导肿瘤细胞凋亡信号转导通路研究进展

周　琳，黄景嘉，罗志勇^*

中南大学湘雅医学院 生物科学与技术学院分子生物学研究中心，长沙 410078

摘　要：摘  要：人参皂苷-Rh2诱导肿瘤细胞凋亡机制复杂，且不同机制间相互联系。它主要通过调节细胞周期蛋白依赖性激酶复合物特异性信号传递引发细胞周期阻滞诱导细胞凋亡，或通过调控细胞信号转导通路，如ROS、Ca2+、PKC、JNK介导的线粒体信号通路和TRAIL-R1(DR4)介导的死亡受体信号通路等诱导肿瘤细胞凋亡。
关键词：人参皂苷-Rh2；肿瘤；周期蛋白依赖性激酶；信号转导通路；细胞凋亡

Progress in the study of tumor apoptosis signalling pathway induced by ginsenoside-Rh2

ZHOU Lin， HUANG Jing-jia， LUO Zhi-yong^*

Molecular Biology Research Center， School of Biological Science and Technology， XiangYa School of Medicine， Central South University， Changsha 410078， China

Abstract: Abstract: Ginsenoside-Rh2-induced tumor apoptosis signaling pathways are complicated and always involved in cross-talking among different pathways. It can cause tumor apoptosis by inducing cell cycle arrest or regulating ROS， Ca2+， PKC， or JNK-mediated cell signaling pathways and TRAIL-R1(DR4)-mediated death receptor pathways.
Key words: ginsenoside-Rh2; tumor; cyclin-dependent kinase; signal transduction pathway; apoptosis