《生命科学》 2010, 22(5): 401-404

Id-1在恶性肿瘤发生中的作用及其机制

郭斌¹， 张成梅²， 刘少华^1*

（1 山东大学齐鲁医院 口腔颌面外科，济南 250012；2 山东大学动物实验中心，济南 250012）

摘　要：摘　要: 分化抑制因子-1(inhibitor of differentiation protein 1， Id-1)是Id转录调节蛋白家族成员之一，属于螺旋-环-螺旋蛋白超家族成员。早期对Id-1的研究认为其主要作用是负向调节正常细胞的分化。近年来研究表明，Id-1在多种肿瘤中过表达并通过多条信号通路促进肿瘤的发生，现就Id-1在肿瘤发生中的作用及其作用机制作一综述。
关键词:分化抑制因子-1；肿瘤发生；机制

The roles and mechanisms of Id-1 in tumorigenesis

GUO Bin¹， ZHANG Cheng-mei²， LIU Shao-hua^1*

1 Department of Oral and Maxillofacial Surgery， Qilu Hospital， Shandong University， Jinan 250012， China; 2 Experimental Animal Center， Shandong University， Jinan 250012， China

Abstract: Abstact: Id-1 (inhibitor of differentiation protein 1) is a member of Id protein family， belongs to the helix-loop-helix proteins superfamily. Early studies have shown that Id-1 mainly acted as a negative regulator of cell differetiation. Recently， Id-1 overexpression has been found in plenty of cancers by promoting tumorigenesis through several  signal pathways. This review will focus on the roles of Id-1 in tumorigenesis and its relative mechanisms.
Key words: inhibitor of differentiation protein 1; tumorigenesis; mechanism