《生命科学》 2010, 22(8): 797-800

CTHRC1与肿瘤关系的研究进展

王萍12， 房静远1

(1 上海交通大学医学院附属仁济医院 上海市消化疾病研究所 200001 2 上海交通大学医学院附属第九人民医院 消化内科200011)

摘　要：摘　要：胶原三股螺旋重复蛋白1基因是从大鼠正常动脉和受损动脉中筛选出的差异表达基因，其通过TGF-b和Wnt/PCP通路发挥作用，使胶原生成减少，促进细胞迁移。在多种肿瘤中发现CTHRC1异常表达，并与肿瘤转移相关。该文就CTHRC1与肿瘤的关系作一综述。
关键词：胶原三股螺旋重复蛋白1；肿瘤；TGF-b通路；Wnt/PCP通路

The relationship between CTHRC1 and cancer

WANG Ping1，2， FANG Jing-yuan1*

(1 Shanghai Institute of Digestive Diseases， Renji Hospital， Affiliated to Shanghai Jiao Tong University School of Medicine， Shanghai 200001， China; 2 Department of Gastroenterology， No.9 Peoples' Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200011， China)

Abstract: Abstract: CTHRC1 gene was first found in a screening for differentially expressed sequences in balloon-injured versus normal rat arteries，which is involved in TGF-b signaling and Wnt signaling，limiting collagen matrix deposition and promoting cell migration. Aberrant expression of CTHRC1 is widely present in human solid cancers and seems to be associated with cancer tissue invasion and metastasis. In this article，  authors reviewed the relationship between CTHRC1 and cancer.
Keywords: collagen triple helix repeat containing 1; cancer; TGF-b signaling; Wnt/PCP signaling